Entity Details

Primary name CSK21_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP68400
EntryNameCSK21_HUMAN
FullNameCasein kinase II subunit alpha
TaxID9606
Evidenceevidence at protein level
Length391
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesCSNK2A1

GO terms

Show/Hide Table
GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005956 protein kinase CK2 complex
GO:0006457 protein folding
GO:0006468 protein phosphorylation
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006915 apoptotic process
GO:0007076 mitotic chromosome condensation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0016055 Wnt signaling pathway
GO:0016236 macroautophagy
GO:0016301 kinase activity
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030307 positive regulation of cell growth
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0047485 protein N-terminus binding
GO:0048511 rhythmic process
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0061077 chaperone-mediated protein folding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1905818 regulation of chromosome separation
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB01765 (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acidDrugbanksmall molecule
DB02170 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-OneDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03035 1,8-Di-Hydroxy-4-Nitro-AnthraquinoneDrugbanksmall molecule
DB03127 BenzamidineDrugbanksmall molecule
DB03924 5,8-Di-Amino-1,4-Dihydroxy-AnthraquinoneDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB04462 Tetrabromo-2-BenzotriazoleDrugbanksmall molecule
DB04719 DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINEDrugbanksmall molecule
DB04720 S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLEDrugbanksmall molecule
DB04721 N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLEDrugbanksmall molecule
DB07715 EmodinDrugbanksmall molecule
DB07802 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONEDrugbanksmall molecule
DB08338 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-oneDrugbanksmall molecule
DB08340 N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINEDrugbanksmall molecule
DB08345 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILEDrugbanksmall molecule
DB08353 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILEDrugbanksmall molecule
DB08354 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILEDrugbanksmall molecule
DB08360 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILEDrugbanksmall molecule
DB08362 N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDEDrugbanksmall molecule
DB08473 DichlororibofuranosylbenzimidazoleDrugbanksmall molecule
DB08660 QuinalizarinDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule