Entity Details

Primary name RB_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP13405
EntryNameRB_MOUSE
FullNameRetinoblastoma-associated protein
TaxID10090
Evidenceevidence at protein level
Length921
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesRb1

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0003180 aortic valve morphogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005819 spindle
GO:0006325 chromatin organization
GO:0006469 negative regulation of protein kinase activity
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0008024 cyclin/CDK positive transcription elongation factor complex
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030308 negative regulation of cell growth
GO:0031134 sister chromatid biorientation
GO:0031175 neuron projection development
GO:0031625 ubiquitin protein ligase binding
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034349 glial cell apoptotic process
GO:0035189 Rb-E2F complex
GO:0035914 skeletal muscle cell differentiation
GO:0042551 neuron maturation
GO:0042802 identical protein binding
GO:0043353 enucleate erythrocyte differentiation
GO:0043550 regulation of lipid kinase activity
GO:0045445 myoblast differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048565 digestive tract development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051146 striated muscle cell differentiation
GO:0051219 phosphoprotein binding
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0061676 importin-alpha family protein binding
GO:0071459 protein localization to chromosome, centromeric region
GO:0071466 cellular response to xenobiotic stimulus
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071922 regulation of cohesin loading
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284 hepatocyte apoptotic process
GO:0097718 disordered domain specific binding
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1902948 negative regulation of tau-protein kinase activity
GO:1903055 positive regulation of extracellular matrix organization
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:1904028 positive regulation of collagen fibril organization
GO:1904761 negative regulation of myofibroblast differentiation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002719 Retinoblastoma-associated protein, B-boxDomainDomain
IPR002720 Retinoblastoma-associated protein, A-boxDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR015030 Retinoblastoma-associated protein, C-terminalDomainDomain
IPR024599 Retinoblastoma-associated protein, N-terminalDomainDomain
IPR028309 Retinoblastoma protein familyFamilyFamily
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
RB_MOUSEHMGB1_MOUSEMINT11748221 details
RB_MOUSEPP1G_MOUSEBioGRID, IntAct17274640 details
RB_MOUSEPAX3_MOUSEIntAct9464541 details
RB_MOUSEVSX2_MOUSEIntAct9464541 details
RB_MOUSESMCA4_MOUSEBioGRID, IntAct7923370 details
RB_MOUSEIFI2_MOUSEUniProt7890747 details
RB_MOUSECCND1_MOUSEBioGRID, IntAct15084261 9191053 details
RB_MOUSERUNX2_MOUSEBioGRID20211142 details
RB_MOUSECEBPD_MOUSEBioGRID20211142 8946919 details
RB_MOUSEID2_MOUSEBioGRID20211142 details
RB_MOUSEKMT5C_MOUSEBioGRID15750587 details
RB_MOUSEKMT5B_MOUSEBioGRID15750587 details
RB_MOUSECDK2_MOUSEBioGRID16102793 18356301 details
RB_MOUSECDK4_MOUSEBioGRID11254678 15158336 8547220 details
RB_MOUSEE2F1_MOUSEBioGRID12799438 28559429 30109252 details
RB_MOUSECSK21_HUMANBioGRID21652635 details
RB_MOUSECDK9_MOUSEBioGRID9827693 details
RB_MOUSERBAK_MOUSEBioGRID10702291 details
RB_MOUSECDK6_MOUSEBioGRID11254678 details
RB_MOUSECEBPA_MOUSEBioGRID8946919 details
RB_MOUSECEBPB_MOUSEBioGRID8946919 details
RB_MOUSECDK2_HUMANBioGRID9840932 details
RB_MOUSECDK4_HUMANBioGRID9840932 details
RB_MOUSEIFI5B_MOUSEMINT16458891 details
RB_MOUSEIFI4_MOUSEMINT16458891 details
RB_MOUSEDGKZ_MOUSEIntAct16286473 details
RB_MOUSEHMGA2_MOUSEBioGRID, IntAct16766265 32325033 details
RB_MOUSEPP1A_MOUSEIntAct17274640 details
RB_MOUSEPP1B_MOUSEIntAct17274640 details
RB_MOUSEANM2_MOUSEIntAct16616919 details
RB_MOUSEPDX1_MOUSEMINT21399612 details
RB_MOUSECCNC_MOUSEIntAct15084261 details
RB_MOUSECCND3_MOUSEIntAct15084261 details
RB_MOUSEGATA1_HUMANBioGRID, DIP19513100 details
RB_MOUSEGATA1_MOUSEDIP19513100 details
RB_MOUSEE2F3_MOUSEDIP20016602 details
RB_MOUSEHDAC1_MOUSEBioGRID10409740 11684023 details
RB_MOUSEFOG1_HUMANBioGRID19513100 details
RB_MOUSEPSD10_MOUSEBioGRID17292836 30109252 details
RB_MOUSENDF1_MOUSEBioGRID15701640 details
RB_MOUSEMO4L1_MOUSEBioGRID15367658 details
RB_MOUSEMOFA1_MOUSEBioGRID15367658 details
RB_MOUSEJARD2_MOUSEBioGRID15870077 details
RB_MOUSEPAX2_MOUSEBioGRID12200151 details
RB_MOUSEKPCB_MOUSEBioGRID11805327 details