Entity Details

Primary name DAB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98082
EntryNameDAB2_HUMAN
FullNameDisabled homolog 2
TaxID9606
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesDAB2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001650 fibrillar center
GO:0001934 positive regulation of protein phosphorylation
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0007275 multicellular organism development
GO:0008022 protein C-terminus binding
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0030136 clathrin-coated vesicle
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030665 clathrin-coated vesicle membrane
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035026 leading edge cell differentiation
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061024 membrane organization
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000370 positive regulation of clathrin-dependent endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Membrane

Domains

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DomainNameCategoryType
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink