Entity Details

Primary name XIAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98170
EntryNameXIAP_HUMAN
FullNameE3 ubiquitin-protein ligase XIAP
TaxID9606
Evidenceevidence at protein level
Length497
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesXIAP

GO terms

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GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0006974 cellular response to DNA damage stimulus
GO:0016055 Wnt signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045088 regulation of innate immune response
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0055070 copper ion homeostasis
GO:0061630 ubiquitin protein ligase activity
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902530 positive regulation of protein linear polyubiquitination
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001370 BIR repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR042579 XIAP/BIRC8, UBA domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02628 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-AmideDrugbanksmall molecule
DB04209 DequaliniumDrugbanksmall molecule
DB04612 N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDEDrugbanksmall molecule
DB06184 AEG35156Drugbanksmall molecule

Interactions

4 interactions