Entity Details

Primary name CLH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00610
EntryNameCLH1_HUMAN
FullNameClathrin heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length1675
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesCLTC

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0001649 osteoblast differentiation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0006914 autophagy
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031623 receptor internalization
GO:0032051 clathrin light chain binding
GO:0032588 trans-Golgi network membrane
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032991 protein-containing complex
GO:0033572 transferrin transport
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042147 retrograde transport, endosome to Golgi
GO:0042470 melanosome
GO:0045334 clathrin-coated endocytic vesicle
GO:0048268 clathrin coat assembly
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051301 cell division
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060236 regulation of mitotic spindle organization
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0071439 clathrin complex
GO:0072583 clathrin-dependent endocytosis
GO:0072686 mitotic spindle
GO:0097718 disordered domain specific binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903561 extracellular vesicle
GO:1990381 ubiquitin-specific protease binding
GO:1990498 mitotic spindle microtubule

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

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DomainNameCategoryType
IPR000547 Clathrin, heavy chain/VPS, 7-fold repeatRepeatRepeat
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR015348 Clathrin, heavy chain, linker, core motifDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016025 Clathrin heavy chain, N-terminalFamilyHomologous superfamily
IPR016341 Clathrin, heavy chainFamilyFamily
IPR022365 Clathrin, heavy chain, propeller repeatRepeatRepeat

Diseases

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Interactions

4 interactions