Entity Details

Primary name RUNX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01196
EntryNameRUNX1_HUMAN
FullNameRunt-related transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length453
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesRUNX1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002062 chondrocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0010755 regulation of plasminogen activation
GO:0016513 core-binding factor complex
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0030111 regulation of Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0032743 positive regulation of interleukin-2 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045589 regulation of regulatory T cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048935 peripheral nervous system neuron development
GO:0050855 regulation of B cell receptor signaling pathway
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061026 cardiac muscle tissue regeneration
GO:0071425 hematopoietic stem cell proliferation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1903055 positive regulation of extracellular matrix organization
GO:1905203 regulation of connective tissue replacement
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000040 Acute myeloid leukemia 1 protein (AML1)/RuntFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013524 Runt domainDomainDomain
IPR013711 Runx, C-terminal domainDomainDomain
IPR016554 Runt-related transcription factor RUNXFamilyFamily
IPR027384 Runx, central domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
RUNX1_HUMANPEBB_MOUSEBioGRID25066130 details
RUNX1_HUMANHIPK2_MOUSEBioGRID30755814 details