Entity Details

Primary name EXOSX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01780
EntryNameEXOSX_HUMAN
FullNameExosome component 10
TaxID9606
Evidenceevidence at protein level
Length885
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesEXOSC10

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000460 maturation of 5.8S rRNA
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0004532 exoribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0016020 membrane
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0035327 transcriptionally active chromatin
GO:0070034 telomerase RNA binding
GO:0071028 nuclear mRNA surveillance
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process
GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071039 nuclear polyadenylation-dependent CUT catabolic process
GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process
GO:0071044 histone mRNA catabolic process
GO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing
GO:1904872 regulation of telomerase RNA localization to Cajal body

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002121 HRDC domainDomainDomain
IPR002562 3'-5' exonuclease domainDomainDomain
IPR010997 HRDC-like superfamilyFamilyHomologous superfamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012588 Exosome-associated factor Rrp6, N-terminalDomainDomain

Diseases

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Interactions

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