Entity Details

Primary name PO5F1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01860
EntryNamePO5F1_HUMAN
FullNamePOU domain, class 5, transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOU5F1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0009786 regulation of asymmetric cell division
GO:0010468 regulation of gene expression
GO:0031625 ubiquitin protein ligase binding
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060913 cardiac cell fate determination
GO:0060965 negative regulation of gene silencing by miRNA
GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR015585 POU domain-containing protein, class 5FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00368 NorepinephrineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule

Interactions

3 interactions