Entity Details

Primary name DNMT1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP13864
EntryNameDNMT1_MOUSE
FullNameDNA (cytosine-5)-methyltransferase 1
TaxID10090
Evidenceevidence at protein level
Length1620
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesDnmt1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000792 heterochromatin
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005721 pericentric heterochromatin
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0007265 Ras protein signal transduction
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008327 methyl-CpG binding
GO:0009008 DNA-methyltransferase activity
GO:0010216 maintenance of DNA methylation
GO:0010424 DNA methylation on cytosine within a CG sequence
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016458 gene silencing
GO:0019904 protein domain specific binding
GO:0030331 estrogen receptor binding
GO:0032776 DNA methylation on cytosine
GO:0032991 protein-containing complex
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042826 histone deacetylase binding
GO:0043025 neuronal cell body
GO:0043045 DNA methylation involved in embryo development
GO:0044026 DNA hypermethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046500 S-adenosylmethionine metabolic process
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0071230 cellular response to amino acid stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
GO:1905931 negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
GO:1990841 promoter-specific chromatin binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001025 Bromo adjacent homology (BAH) domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR010506 DMAP1-binding domainDomainDomain
IPR017198 DNA (cytosine-5)-methyltransferase 1-likeFamilyFamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR031303 DNA methylase, C-5 cytosine-specific, conserved siteSiteConserved site
IPR043151 Bromo adjacent homology (BAH) domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table