Entity Details

Primary name KPCE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02156
EntryNameKPCE_HUMAN
FullNameProtein kinase C epsilon type
TaxID9606
Evidenceevidence at protein level
Length737
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCE

GO terms

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GOName
GO:0002281 macrophage activation involved in immune response
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008047 enzyme activator activity
GO:0010634 positive regulation of epithelial cell migration
GO:0010763 positive regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0018105 peptidyl-serine phosphorylation
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030546 signaling receptor activator activity
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032467 positive regulation of cytokinesis
GO:0035276 ethanol binding
GO:0035556 intracellular signal transduction
GO:0035641 locomotory exploration behavior
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043278 response to morphine
GO:0043410 positive regulation of MAPK cascade
GO:0045111 intermediate filament cytoskeleton
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050996 positive regulation of lipid catabolic process
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051301 cell division
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070257 positive regulation of mucus secretion
GO:0071361 cellular response to ethanol
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071456 cellular response to hypoxia
GO:0071889 14-3-3 protein binding
GO:0071944 cell periphery
GO:0090303 positive regulation of wound healing
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2001031 positive regulation of cellular glucuronidation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027274 Protein kinase C, epsilonFamilyFamily
IPR034669 Novel protein kinase C epsilon, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB06064 KAI-1455Drugbanksmall molecule
DB11752 Bryostatin 1Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KPCE_HUMANMARCS_MOUSEBioGRID7588787 details