Entity Details

Primary name MP2K1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02750
EntryNameMP2K1_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 1
TaxID9606
Evidenceevidence at protein level
Length393
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0018107 peptidyl-threonine phosphorylation
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030878 thyroid gland development
GO:0032872 regulation of stress-activated MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB03115 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideDrugbanksmall molecule
DB05239 CobimetinibDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB06892 (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamideDrugbanksmall molecule
DB07046 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamideDrugbanksmall molecule
DB07101 PD-0325901Drugbanksmall molecule
DB08130 N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamineDrugbanksmall molecule
DB08208 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDEDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule

Interactions

3 interactions