Entity Details

Primary name KMT2A_HUMAN
Entity type UniProt
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Details

AccessionQ03164
EntryNameKMT2A_HUMAN
FullNameHistone-lysine N-methyltransferase 2A
TaxID9606
Evidenceevidence at protein level
Length3969
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesKMT2A

GO terms

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GOName
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008270 zinc ion binding
GO:0032411 positive regulation of transporter activity
GO:0032922 circadian regulation of gene expression
GO:0035097 histone methyltransferase complex
GO:0035162 embryonic hemopoiesis
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043984 histone H4-K16 acetylation
GO:0044648 histone H3-K4 dimethylation
GO:0045322 unmethylated CpG binding
GO:0045652 regulation of megakaryocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051568 histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0065003 protein-containing complex assembly
GO:0070577 lysine-acetylated histone binding
GO:0071339 MLL1 complex
GO:0071440 regulation of histone H3-K14 acetylation
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation
GO:0106363 protein-cysteine methyltransferase activity
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1905642 negative regulation of DNA methylation
GO:2000615 regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001487 BromodomainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR003888 FY-rich, N-terminalDomainDomain
IPR003889 FY-rich, C-terminalDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR016569 Methyltransferase, trithoraxFamilyFamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR034732 Extended PHD (ePHD) domainDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037927 Histone-lysine N-methyltransferase 2AFamilyFamily
IPR041958 KMT2A, ePHD domainDomainDomain
IPR042023 KMT2A, PHD domain 1DomainDomain
IPR042025 KMT2A, PHD domain 2DomainDomain
IPR044133 KMT2A, PHD domain 3DomainDomain

Diseases

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