Entity Details

Primary name ERCC6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03468
EntryNameERCC6_HUMAN
FullNameDNA excision repair protein ERCC-6
TaxID9606
Evidenceevidence at protein level
Length1493
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesERCC6

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000077 DNA damage checkpoint signaling
GO:0000303 response to superoxide
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006366 transcription by RNA polymerase II
GO:0006979 response to oxidative stress
GO:0007256 obsolete activation of JNKK activity
GO:0007257 obsolete activation of JUN kinase activity
GO:0008022 protein C-terminus binding
GO:0008023 transcription elongation factor complex
GO:0008094 ATPase, acting on DNA
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0009636 response to toxic substance
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0030296 protein tyrosine kinase activator activity
GO:0031175 neuron projection development
GO:0032508 DNA duplex unwinding
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0035264 multicellular organism growth
GO:0043044 ATP-dependent chromatin remodeling
GO:0044877 protein-containing complex binding
GO:0045494 photoreceptor cell maintenance
GO:0045739 positive regulation of DNA repair
GO:0045815 positive regulation of gene expression, epigenetic
GO:0047485 protein N-terminus binding
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0070063 RNA polymerase binding
GO:0070615 nucleosome-dependent ATPase activity
GO:0090734 site of DNA damage
GO:0097680 double-strand break repair via classical nonhomologous end joining
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ERCC6_HUMANABL1_MOUSEIntAct17626041 details