Entity Details

Primary name TF65_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04206
EntryNameTF65_HUMAN
FullNameTranscription factor p65
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesRELA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0001942 hair follicle development
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006117 acetaldehyde metabolic process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0010033 response to organic substance
GO:0010224 response to UV-B
GO:0014040 positive regulation of Schwann cell differentiation
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032481 positive regulation of type I interferon production
GO:0032495 response to muramyl dipeptide
GO:0032570 response to progesterone
GO:0032735 positive regulation of interleukin-12 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032868 response to insulin
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033234 negative regulation of protein sumoylation
GO:0033590 response to cobalamin
GO:0034097 response to cytokine
GO:0035525 NF-kappaB p50/p65 complex
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0035994 response to muscle stretch
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042177 negative regulation of protein catabolic process
GO:0042277 peptide binding
GO:0042301 phosphate ion binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042805 actinin binding
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0043278 response to morphine
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0047485 protein N-terminus binding
GO:0050727 regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070301 cellular response to hydrogen peroxide
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071532 ankyrin repeat binding
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:0140297 DNA-binding transcription factor binding
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902004 positive regulation of amyloid-beta formation
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904385 cellular response to angiotensin
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000630 positive regulation of miRNA metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000451 NF-kappa-B/DorsalFamilyFamily
IPR002909 IPT domainDomainDomain
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR030492 Rel homology domain, conserved siteSiteConserved site
IPR030495 Transcription factor RelA (p65)FamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR033926 NFkappaB IPT domainDomainDomain
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08908 Dimethyl fumarateDrugbanksmall molecule
DB14059 SC-236Drugbanksmall molecule