Entity Details

Primary name IF4G1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04637
EntryNameIF4G1_HUMAN
FullNameEukaryotic translation initiation factor 4 gamma 1
TaxID9606
Evidenceevidence at protein level
Length1599
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF4G1

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001662 behavioral fear response
GO:0002191 cap-dependent translational initiation
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008135 translation factor activity, RNA binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0010494 cytoplasmic stress granule
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0016020 membrane
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0030307 positive regulation of cell growth
GO:0031369 translation initiation factor binding
GO:0031669 cellular response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032502 developmental process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034645 cellular macromolecule biosynthetic process
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042802 identical protein binding
GO:0043488 regulation of mRNA stability
GO:0045666 positive regulation of neuron differentiation
GO:0060090 molecular adaptor activity
GO:0060964 regulation of gene silencing by miRNA
GO:0080135 regulation of cellular response to stress
GO:0097009 energy homeostasis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901215 negative regulation of neuron death
GO:1905537 positive regulation of eukaryotic translation initiation factor 4F complex assembly
GO:1905606 regulation of presynapse assembly
GO:1905612 positive regulation of mRNA cap binding
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1905696 regulation of polysome binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003307 W2 domainDomainDomain
IPR003890 MIF4G-like, type 3DomainDomain
IPR003891 Initiation factor eIF-4 gamma, MA3DomainDomain
IPR016021 MIF4G-like domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR037584 Eukaryotic translation initiation factor 4 gamma 1FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
IF4G1_HUMANIF4E2_MOUSEIntAct15153109 details
IF4G1_HUMANIF4E_MOUSEBioGRID12149653 details