Entity Details

Primary name KPCT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04759
EntryNameKPCT_HUMAN
FullNameProtein kinase C theta type
TaxID9606
Evidenceevidence at protein level
Length706
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCQ

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001558 regulation of cell growth
GO:0001772 immunological synapse
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006509 membrane protein ectodomain proteolysis
GO:0006954 inflammatory response
GO:0007411 axon guidance
GO:0016235 aggresome
GO:0018105 peptidyl-serine phosphorylation
GO:0030168 platelet activation
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032740 positive regulation of interleukin-17 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034451 centriolar satellite
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0045652 regulation of megakaryocyte differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051973 positive regulation of telomerase activity
GO:0060326 cell chemotaxis
GO:0070233 negative regulation of T cell apoptotic process
GO:0090330 regulation of platelet aggregation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904355 positive regulation of telomere capping
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000570 positive regulation of T-helper 2 cell activation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027264 Protein kinase C, thetaFamilyFamily
IPR034668 Novel protein kinase C theta, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB02482 PhosphonothreonineDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KPCT_HUMANCD28_MOUSEInnateDB21964608 details