Entity Details

Primary name FAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05397
EntryNameFAK1_HUMAN
FullNameFocal adhesion kinase 1
TaxID9606
Evidenceevidence at protein level
Length1052
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPTK2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001725 stress fiber
GO:0001890 placenta development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003779 actin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008432 JUN kinase binding
GO:0010594 regulation of endothelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030010 establishment of cell polarity
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035995 detection of muscle stretch
GO:0036064 ciliary basal body
GO:0038007 netrin-activated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0043066 negative regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048870 cell motility
GO:0051493 regulation of cytoskeleton organization
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060396 growth hormone receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:0120041 positive regulation of macrophage proliferation
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR005189 Focal adhesion kinase, targeting (FAT) domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamilyFamilyHomologous superfamily
IPR041390 Focal adhesion kinase, N-terminalDomainDomain
IPR041784 FAK1/PYK2, FERM domain C-lobeDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06423 EndostatinDrugbankbiotech
DB07248 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINEDrugbanksmall molecule
DB07460 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions