Entity Details

Primary name KPCZ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05513
EntryNameKPCZ_HUMAN
FullNameProtein kinase C zeta type
TaxID9606
Evidenceevidence at protein level
Length592
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCZ

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001725 stress fiber
GO:0001954 positive regulation of cell-matrix adhesion
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007616 long-term memory
GO:0008284 positive regulation of cell population proliferation
GO:0014069 postsynaptic density
GO:0015459 potassium channel regulator activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016363 nuclear matrix
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030010 establishment of cell polarity
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031584 activation of phospholipase D activity
GO:0031982 vesicle
GO:0032148 activation of protein kinase B activity
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0035748 myelin sheath abaxonal region
GO:0043066 negative regulation of apoptotic process
GO:0043203 axon hillock
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045179 apical cortex
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051222 positive regulation of protein transport
GO:0051346 negative regulation of hydrolase activity
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0060291 long-term synaptic potentiation
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0071889 14-3-3 protein binding
GO:0072659 protein localization to plasma membrane
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990138 neuron projection extension
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Endosome
Membrane

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012233 Protein kinase CFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR034662 Atypical Protein Kinase C zeta, catalytic domainDomainDomain
IPR034877 Protein kinase C, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule

Interactions

3 interactions