Entity Details

Primary name LRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07954
EntryNameLRP1_HUMAN
FullNameProlow-density lipoprotein receptor-related protein 1
TaxID9606
Evidenceevidence at protein level
Length4544
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesLRP1

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0002020 protease binding
GO:0002265 astrocyte activation involved in immune response
GO:0003723 RNA binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0006629 lipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007041 lysosomal transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007568 aging
GO:0008283 cell population proliferation
GO:0010715 regulation of extracellular matrix disassembly
GO:0010875 positive regulation of cholesterol efflux
GO:0010942 positive regulation of cell death
GO:0010977 negative regulation of neuron projection development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016964 alpha-2 macroglobulin receptor activity
GO:0021987 cerebral cortex development
GO:0030136 clathrin-coated vesicle
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030226 apolipoprotein receptor activity
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0031623 receptor internalization
GO:0032050 clathrin heavy chain binding
GO:0032092 positive regulation of protein binding
GO:0032370 positive regulation of lipid transport
GO:0032374 regulation of cholesterol transport
GO:0032429 regulation of phospholipase A2 activity
GO:0032593 insulin-responsive compartment
GO:0032956 regulation of actin cytoskeleton organization
GO:0034185 apolipoprotein binding
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035909 aorta morphogenesis
GO:0038023 signaling receptor activity
GO:0038024 cargo receptor activity
GO:0042157 lipoprotein metabolic process
GO:0042953 lipoprotein transport
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0043395 heparan sulfate proteoglycan binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044242 cellular lipid catabolic process
GO:0044295 axonal growth cone
GO:0044877 protein-containing complex binding
GO:0045056 transcytosis
GO:0045177 apical part of cell
GO:0045807 positive regulation of endocytosis
GO:0048691 positive regulation of axon extension involved in regeneration
GO:0048694 positive regulation of collateral sprouting of injured axon
GO:0050766 positive regulation of phagocytosis
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051895 negative regulation of focal adhesion assembly
GO:0061642 chemoattraction of axon
GO:0070325 lipoprotein particle receptor binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097242 amyloid-beta clearance
GO:0098797 plasma membrane protein complex
GO:0150093 amyloid-beta clearance by transcytosis
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:0150104 transport across blood-brain barrier
GO:1900149 positive regulation of Schwann cell migration
GO:1900223 positive regulation of amyloid-beta clearance
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1904109 positive regulation of cholesterol import
GO:1904300 positive regulation of transcytosis
GO:1904646 cellular response to amyloid-beta
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1905049 negative regulation of metallopeptidase activity
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi outpost
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR032485 Domain of unknown function DUF5050DomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB06245 LanoteplaseDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
LRP1_HUMANTSP2_MOUSEI2D20472562 details