Entity Details

Primary name PP2BA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08209
EntryNamePP2BA_HUMAN
FullNameSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPPP3CA

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0004722 protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007420 brain development
GO:0007568 aging
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016018 cyclosporin A binding
GO:0016311 dephosphorylation
GO:0019897 extrinsic component of plasma membrane
GO:0019899 enzyme binding
GO:0030018 Z disc
GO:0030335 positive regulation of cell migration
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0033555 multicellular organismal response to stress
GO:0035562 negative regulation of chromatin binding
GO:0036057 slit diaphragm
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0048741 skeletal muscle fiber development
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0051592 response to calcium ion
GO:0060079 excitatory postsynaptic potential
GO:0070262 peptidyl-serine dephosphorylation
GO:0071333 cellular response to glucose stimulus
GO:0097720 calcineurin-mediated signaling
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905205 positive regulation of connective tissue replacement

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041751 PP2B, metallophosphatase domainDomainDomain
IPR043360 PP2BFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08231 Myristic acidDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PP2BA_HUMANFBX32_MOUSEBioGRID15489953 details
PP2BA_HUMANNFAC1_MOUSEMINT9660947 details