Entity Details

Primary name EP300_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ09472
EntryNameEP300_HUMAN
FullNameHistone acetyltransferase p300
TaxID9606
Evidenceevidence at protein level
Length2414
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesEP300

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000123 histone acetyltransferase complex
GO:0001666 response to hypoxia
GO:0001756 somitogenesis
GO:0001966 thigmotaxis
GO:0002039 p53 binding
GO:0002209 behavioral defense response
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006110 regulation of glycolytic process
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007399 nervous system development
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0009887 animal organ morphogenesis
GO:0010484 H3 histone acetyltransferase activity
GO:0010485 H4 histone acetyltransferase activity
GO:0010506 regulation of autophagy
GO:0010742 macrophage derived foam cell differentiation
GO:0010821 regulation of mitochondrion organization
GO:0010976 positive regulation of neuron projection development
GO:0016032 viral process
GO:0016407 acetyltransferase activity
GO:0016573 histone acetylation
GO:0016579 protein deubiquitination
GO:0016746 acyltransferase activity
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0030183 B cell differentiation
GO:0030220 platelet formation
GO:0030324 lung development
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0030851 granulocyte differentiation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031490 chromatin DNA binding
GO:0031648 protein destabilization
GO:0032092 positive regulation of protein binding
GO:0032481 positive regulation of type I interferon production
GO:0032993 protein-DNA complex
GO:0034644 cellular response to UV
GO:0035264 multicellular organism growth
GO:0035855 megakaryocyte development
GO:0036268 swimming
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043627 response to estrogen
GO:0043923 positive regulation by host of viral transcription
GO:0043967 histone H4 acetylation
GO:0043969 histone H2B acetylation
GO:0045444 fat cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045747 positive regulation of Notch signaling pathway
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048156 tau protein binding
GO:0050681 androgen receptor binding
GO:0050821 protein stabilization
GO:0051059 NF-kappaB binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060325 face morphogenesis
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061920 protein propionyltransferase activity
GO:0061921 peptidyl-lysine propionylation
GO:0090043 regulation of tubulin deacetylation
GO:0097157 pre-mRNA intronic binding
GO:0097677 STAT family protein binding
GO:0106226 peptide 2-hydroxyisobutyryltransferase activity
GO:0120301 histone lactyltransferase activity
GO:0140065 peptide butyryltransferase activity
GO:0140066 peptidyl-lysine crotonylation
GO:0140067 peptidyl-lysine butyrylation
GO:0140068 histone crotonyltransferase activity
GO:0140069 histone butyryltransferase activity
GO:1900034 regulation of cellular response to heat
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904837 beta-catenin-TCF complex assembly
GO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000197 Zinc finger, TAZ-typeDomainDomain
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR001487 BromodomainDomainDomain
IPR003101 Coactivator CBP, KIX domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010303 CREB-binding protein/p300, atypical RING domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013178 Histone acetyltransferase Rtt109/CBPFamilyFamily
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlockingDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR031162 CBP/p300-type histone acetyltransferase domainDomainDomain
IPR035898 TAZ domain superfamilyFamilyHomologous superfamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR036529 Coactivator CBP, KIX domain superfamilyFamilyHomologous superfamily
IPR037073 Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamilyFamilyHomologous superfamily
IPR038547 CBP/p300, atypical RING domain superfamilyFamilyHomologous superfamily
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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