Entity Details

Primary name SRBP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12772
EntryNameSRBP2_HUMAN
FullNameSterol regulatory element-binding protein 2
TaxID9606
Evidenceevidence at protein level
Length1141
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesSREBF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0007399 nervous system development
GO:0008022 protein C-terminus binding
GO:0008203 cholesterol metabolic process
GO:0008593 regulation of Notch signaling pathway
GO:0009267 cellular response to starvation
GO:0010886 positive regulation of cholesterol storage
GO:0012507 ER to Golgi transport vesicle membrane
GO:0019216 regulation of lipid metabolic process
GO:0032933 SREBP signaling pathway
GO:0032937 SREBP-SCAP-Insig complex
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0090370 negative regulation of cholesterol efflux
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903146 regulation of autophagy of mitochondrion
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Golgi apparatus membrane
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SRBP2_HUMANIMB1_MOUSEIntAct14645851 details
SRBP2_HUMANSCAP_MOUSEBioGRID12202038 details