Entity Details

Primary name EPS8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12929
EntryNameEPS8_HUMAN
FullNameEpidermal growth factor receptor kinase substrate 8
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesEPS8

GO terms

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GOName
GO:0003779 actin binding
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0010458 exit from mitosis
GO:0016601 Rac protein signal transduction
GO:0030426 growth cone
GO:0030832 regulation of actin filament length
GO:0031267 small GTPase binding
GO:0031982 vesicle
GO:0032420 stereocilium
GO:0032587 ruffle membrane
GO:0035023 regulation of Rho protein signal transduction
GO:0035591 signaling adaptor activity
GO:0036336 dendritic cell migration
GO:0045202 synapse
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
GO:0051764 actin crosslink formation
GO:0070062 extracellular exosome
GO:0070358 actin polymerization-dependent cell motility
GO:1900029 positive regulation of ruffle assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013625 Tensin/EPS8 phosphotyrosine-binding domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR030222 Epidermal growth factor receptor kinase substrate 8FamilyFamily
IPR033928 Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domainDomainDomain
IPR035462 Eps8, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR039801 Epidermal growth factor receptor kinase substrate 8-likeFamilyFamily
IPR041418 SAM domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
EPS8_HUMANABI1_MOUSEIntAct9010225 details