Entity Details

Primary name TRAF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12933
EntryNameTRAF2_HUMAN
FullNameTNF receptor-associated factor 2
TaxID9606
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTRAF2

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0002637 regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0012506 vesicle membrane
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030163 protein catabolic process
GO:0030674 protein-macromolecule adaptor activity
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032743 positive regulation of interleukin-2 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034622 cellular protein-containing complex assembly
GO:0034976 response to endoplasmic reticulum stress
GO:0035631 CD40 receptor complex
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043120 tumor necrosis factor binding
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043507 positive regulation of JUN kinase activity
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0046330 positive regulation of JNK cascade
GO:0046625 sphingolipid binding
GO:0048255 mRNA stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0065003 protein-containing complex assembly
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070534 protein K63-linked ubiquitination
GO:0071550 death-inducing signaling complex assembly
GO:0071732 cellular response to nitric oxide
GO:0097057 TRAF2-GSTP1 complex
GO:0097300 programmed necrotic cell death
GO:0097400 interleukin-17-mediated signaling pathway
GO:1901215 negative regulation of neuron death
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1990604 IRE1-TRAF2-ASK1 complex
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR018957 Zinc finger, C3HC4 RING-typeDomainDomain
IPR027133 TNF receptor-associated factor 2FamilyFamily
IPR032070 TNF receptor-associated factor, BIRC3 binding domainDomainDomain
IPR037305 TNF receptor-associated factor 2, MATH domainDomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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