Entity Details

Primary name NTRK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP15209
EntryNameNTRK2_MOUSE
FullNameBDNF/NT-3 growth factors receptor
TaxID10090
Evidenceevidence at protein level
Length821
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesNtrk2

GO terms

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GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0019222 regulation of metabolic process
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0042803 protein homodimerization activity
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0046548 retinal rod cell development
GO:0046928 regulation of neurotransmitter secretion
GO:0048935 peripheral nervous system neuron development
GO:0051896 regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060041 retina development in camera-type eye
GO:0060175 brain-derived neurotrophic factor-activated receptor activity
GO:0098978 glutamatergic synapse
GO:1902430 negative regulation of amyloid-beta formation
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0007275 multicellular organism development
GO:0007528 neuromuscular junction development
GO:0007612 learning
GO:0009986 cell surface
GO:0019227 neuronal action potential propagation
GO:0022011 myelination in peripheral nervous system
GO:0030426 growth cone
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0046777 protein autophosphorylation
GO:0048403 brain-derived neurotrophic factor binding
GO:0048786 presynaptic active zone
GO:0060291 long-term synaptic potentiation
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:1990090 cellular response to nerve growth factor stimulus
GO:0002020 protease binding
GO:0005829 cytosol
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0021954 central nervous system neuron development
GO:0030971 receptor tyrosine kinase binding
GO:0033674 positive regulation of kinase activity
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0050773 regulation of dendrite development
GO:0051965 positive regulation of synapse assembly
GO:0060076 excitatory synapse
GO:0071230 cellular response to amino acid stimulus
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission
GO:0005030 neurotrophin receptor activity
GO:0005768 endosome
GO:0005769 early endosome
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007616 long-term memory
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0014047 glutamate secretion
GO:0021987 cerebral cortex development
GO:0030425 dendrite
GO:0031901 early endosome membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043025 neuronal cell body
GO:0043121 neurotrophin binding
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043408 regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0045211 postsynaptic membrane
GO:0050772 positive regulation of axonogenesis
GO:0098794 postsynapse
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000324 positive regulation of glucocorticoid receptor signaling pathway
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell projection
Early endosome membrane
Cell membrane
Cell junction
Cytoplasm
Endosome membrane

Domains

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DomainNameCategoryType
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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