Entity Details

Primary name TRAF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13114
EntryNameTRAF3_HUMAN
FullNameTNF receptor-associated factor 3
TaxID9606
Evidenceevidence at protein level
Length568
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTRAF3

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008063 Toll signaling pathway
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030162 regulation of proteolysis
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032648 regulation of interferon-beta production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050688 regulation of defense response to virus
GO:0070534 protein K63-linked ubiquitination

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Mitochondrion

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027128 TNF receptor-associated factor 3FamilyFamily
IPR037304 TRAF3, MATH domainDomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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Interactions

3 interactions