Entity Details

Primary name PAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13153
EntryNamePAK1_HUMAN
FullNameSerine/threonine-protein kinase PAK 1
TaxID9606
Evidenceevidence at protein level
Length545
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAK1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001726 ruffle
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell population proliferation
GO:0010763 positive regulation of fibroblast migration
GO:0014704 intercalated disc
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0021549 cerebellum development
GO:0030010 establishment of cell polarity
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031116 positive regulation of microtubule polymerization
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0031965 nuclear membrane
GO:0032147 activation of protein kinase activity
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 wound healing
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding
GO:0043507 positive regulation of JUN kinase activity
GO:0045773 positive regulation of axon extension
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0090063 positive regulation of microtubule nucleation
GO:0090314 positive regulation of protein targeting to membrane
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions