Entity Details

Primary name MP2K5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13163
EntryNameMP2K5_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 5
TaxID9606
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K5

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007507 heart development
GO:0030307 positive regulation of cell growth
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032717 negative regulation of interleukin-8 production
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051247 positive regulation of protein metabolic process
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070375 ERK5 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034851 Dual specificity mitogen-activated protein kinase kinase 5, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MP2K5_HUMANM3K3_MOUSEBioGRID10593883 details