Entity Details

Primary name NMDE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13224
EntryNameNMDE2_HUMAN
FullNameGlutamate receptor ionotropic, NMDA 2B
TaxID9606
Evidenceevidence at protein level
Length1484
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesGRIN2B

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001540 amyloid-beta binding
GO:0004972 NMDA glutamate receptor activity
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0007611 learning or memory
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0017146 NMDA selective glutamate receptor complex
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0045471 response to ethanol
GO:0048013 ephrin receptor signaling pathway
GO:0048167 regulation of synaptic plasticity
GO:0051290 protein heterotetramerization
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0097060 synaptic membrane
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098839 postsynaptic density membrane
GO:0098976 excitatory chemical synaptic transmission
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:2000310 regulation of NMDA receptor activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00659 AcamprosateDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00874 GuaifenesinDrugbanksmall molecule
DB00949 FelbamateDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01520 TenocyclidineDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01956 TaurineDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB05956 EVT-101Drugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06741 GavestinelDrugbanksmall molecule
DB08954 IfenprodilDrugbanksmall molecule
DB09409 Magnesium acetate tetrahydrateDrugbanksmall molecule
DB09481 Magnesium carbonateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NMDE2_HUMANNMDE1_MOUSEBioGRID11897110 details