Entity Details

Primary name GRB10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13322
EntryNameGRB10_HUMAN
FullNameGrowth factor receptor-bound protein 10
TaxID9606
Evidenceevidence at protein level
Length594
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesGRB10

GO terms

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GOName
GO:0005158 insulin receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015042 BPS (Between PH and SH2) domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035036 Growth factor receptor-bound protein 10FamilyFamily
IPR035037 Grb10, SH2DomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039664 GRB/APBB1IPFamilyFamily
IPR039665 APBB1IP, PH domainDomainDomain

Diseases

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Interactions

0 interactions

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