Entity Details

Primary name BIRC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13490
EntryNameBIRC2_HUMAN
FullNameBaculoviral IAP repeat-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length618
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBIRC2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001741 XY body
GO:0001890 placenta development
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007166 cell surface receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016579 protein deubiquitination
GO:0016740 transferase activity
GO:0031398 positive regulation of protein ubiquitination
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0039535 regulation of RIG-I signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045595 regulation of cell differentiation
GO:0047485 protein N-terminus binding
GO:0050727 regulation of inflammatory response
GO:0051087 chaperone binding
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0061630 ubiquitin protein ligase activity
GO:0070266 necroptotic process
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0098770 FBXO family protein binding
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000377 regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001370 BIR repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR041933 BIRC2/BIRC3, UBA domainDomainDomain

Diseases

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