Entity Details

Primary name SQSTM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13501
EntryNameSQSTM_HUMAN
FullNameSequestosome-1
TaxID9606
Evidenceevidence at protein level
Length440
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesSQSTM1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000407 phagophore assembly site
GO:0000422 autophagy of mitochondrion
GO:0000423 mitophagy
GO:0000425 pexophagy
GO:0000932 P-body
GO:0001934 positive regulation of protein phosphorylation
GO:0002376 immune system process
GO:0002931 response to ischemia
GO:0004674 protein serine/threonine kinase activity
GO:0005080 protein kinase C binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0007032 endosome organization
GO:0008104 protein localization
GO:0008270 zinc ion binding
GO:0010821 regulation of mitochondrion organization
GO:0016197 endosomal transport
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016236 macroautophagy
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030017 sarcomere
GO:0030154 cell differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0031397 negative regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035556 intracellular signal transduction
GO:0035973 aggrephagy
GO:0042169 SH2 domain binding
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043231 intracellular membrane-bounded organelle
GO:0044753 amphisome
GO:0044754 autolysosome
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046578 regulation of Ras protein signal transduction
GO:0061635 regulation of protein complex stability
GO:0061912 selective autophagy
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0097225 sperm midpiece
GO:0097413 Lewy body
GO:0098780 response to mitochondrial depolarisation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1905719 protein localization to perinuclear region of cytoplasm

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Late endosome
Lysosome
Nucleus

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR033741 Sequestosome-1, UBA domainDomainDomain
IPR034866 Sequestosome-1, PB1 domainDomainDomain
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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