Entity Details

Primary name ATR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13535
EntryNameATR_HUMAN
FullNameSerine/threonine-protein kinase ATR
TaxID9606
Evidenceevidence at protein level
Length2644
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesATR

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000723 telomere maintenance
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007275 multicellular organism development
GO:0008156 negative regulation of DNA replication
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0031297 replication fork processing
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0034644 cellular response to UV
GO:0036297 interstrand cross-link repair
GO:0042493 response to drug
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777 protein autophosphorylation
GO:0070198 protein localization to chromosome, telomeric region
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0097694 establishment of RNA localization to telomere
GO:0097695 establishment of protein-containing complex localization to telomere
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904884 positive regulation of telomerase catalytic core complex assembly

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR012993 UME domainDomainDomain
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR021133 HEAT, type 2RepeatRepeat
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ATR_HUMANBID_MOUSEBioGRID16122425 16122426 details