Entity Details

Primary name RIPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13546
EntryNameRIPK1_HUMAN
FullNameReceptor-interacting serine/threonine-protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length671
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesRIPK1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005123 death receptor binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0010008 endosome membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010940 positive regulation of necrotic cell death
GO:0016579 protein deubiquitination
GO:0019054 modulation by virus of host cellular process
GO:0031264 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036289 peptidyl-serine autophosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0062099 negative regulation of programmed necrotic cell death
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070513 death domain binding
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071550 death-inducing signaling complex assembly
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097342 ripoptosome
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1990000 amyloid fibril formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR025735 RHIM domainDomainDomain
IPR037934 RIP1, Death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
RIPK1_HUMANM3K8_MOUSEIntAct16291755 details
RIPK1_HUMANNFKB1_MOUSEIntAct16291755 details