Entity Details

Primary name HDAC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13547
EntryNameHDAC1_HUMAN
FullNameHistone deacetylase 1
TaxID9606
Evidenceevidence at protein level
Length482
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHDAC1

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0002039 p53 binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0007492 endoderm development
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010629 negative regulation of gene expression
GO:0016575 histone deacetylation
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033558 protein deacetylase activity
GO:0035851 Krueppel-associated box domain binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042826 histone deacetylase binding
GO:0043025 neuronal cell body
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043922 negative regulation by host of viral transcription
GO:0045652 regulation of megakaryocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051059 NF-kappaB binding
GO:0052548 regulation of endopeptidase activity
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060789 hair follicle placode formation
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070888 E-box binding
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900221 regulation of amyloid-beta clearance
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904837 beta-catenin-TCF complex assembly
GO:1990841 promoter-specific chromatin binding
GO:2000273 positive regulation of signaling receptor activity
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01169 Arsenic trioxideDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02546 VorinostatDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05223 PracinostatDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB08868 FingolimodDrugbanksmall molecule
DB11830 MocetinostatDrugbanksmall molecule
DB12565 AbexinostatDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule