Entity Details

Primary name TDG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13569
EntryNameTDG_HUMAN
FullNameG/T mismatch-specific thymine DNA glycosylase
TaxID9606
Evidenceevidence at protein level
Length410
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesTDG

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0006325 chromatin organization
GO:0008134 transcription factor binding
GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0019104 DNA N-glycosylase activity
GO:0019904 protein domain specific binding
GO:0030983 mismatched DNA binding
GO:0031402 sodium ion binding
GO:0031404 chloride ion binding
GO:0032183 SUMO binding
GO:0035511 oxidative DNA demethylation
GO:0040029 regulation of gene expression, epigenetic
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity
GO:0045008 depyrimidination
GO:0045995 regulation of embryonic development
GO:0080111 DNA demethylation
GO:1902544 regulation of DNA N-glycosylase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003310 G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotesFamilyFamily
IPR005122 Uracil-DNA glycosylase-likeDomainDomain
IPR015637 Uracil DNA glycosylase family 2FamilyFamily
IPR036895 Uracil-DNA glycosylase-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TDG_HUMANESR1_MOUSEIntAct16282588 details