Entity Details

Primary name AVR2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13705
EntryNameAVR2B_HUMAN
FullNameActivin receptor type-2B
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesACVR2B

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009952 anterior/posterior pattern specification
GO:0017002 activin-activated receptor activity
GO:0019838 growth factor binding
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0043235 receptor complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061298 retina vasculature development in camera-type eye
GO:0071363 cellular response to growth factor stimulus
GO:0120163 negative regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AVR2B_HUMANGDF8_MOUSEMINT21054789 details
AVR2B_HUMANDOK1_MOUSEBioGRID11927552 details