Entity Details

Primary name KGP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13976
EntryNameKGP1_HUMAN
FullNamecGMP-dependent protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length671
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPRKG1

GO terms

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GOName
GO:0001764 neuron migration
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005246 calcium channel regulator activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016358 dendrite development
GO:0019934 cGMP-mediated signaling
GO:0030036 actin cytoskeleton organization
GO:0030553 cGMP binding
GO:0030900 forebrain development
GO:0042802 identical protein binding
GO:0043087 regulation of GTPase activity
GO:0060087 relaxation of vascular associated smooth muscle
GO:0090331 negative regulation of platelet aggregation
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002374 cGMP-dependent kinaseFamilyFamily
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR031831 cGMP-dependent protein kinase, N-terminal coiled-coil domainDomainDomain
IPR035014 cGMP-dependent protein kinase, catalytic domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KGP1_HUMANGKAP1_MOUSEMINT10671526 details