Entity Details

Primary name KEAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14145
EntryNameKEAP1_HUMAN
FullNameKelch-like ECH-associated protein 1
TaxID9606
Evidenceevidence at protein level
Length624
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesKEAP1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005884 actin filament
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008134 transcription factor binding
GO:0010506 regulation of autophagy
GO:0016032 viral process
GO:0016234 inclusion body
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034451 centriolar satellite
GO:0034599 cellular response to oxidative stress
GO:0042802 identical protein binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043687 post-translational protein modification
GO:0045604 regulation of epidermal cell differentiation
GO:0071353 cellular response to interleukin-4
GO:0097718 disordered domain specific binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR006652 Kelch repeat type 1RepeatRepeat
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR011705 BTB/Kelch-associatedDomainDomain
IPR015915 Kelch-type beta propellerFamilyHomologous superfamily
IPR017096 BTB-kelch proteinFamilyFamily
IPR030563 Kelch-like ECH-associated protein 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08908 Dimethyl fumarateDrugbanksmall molecule