Entity Details

Primary name DYHC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14204
EntryNameDYHC1_HUMAN
FullNameCytoplasmic dynein 1 heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length4646
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDYNC1H1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0008090 retrograde axonal transport
GO:0008569 minus-end-directed microtubule motor activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0019058 viral life cycle
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030286 dynein complex
GO:0031122 cytoplasmic microtubule organization
GO:0032388 positive regulation of intracellular transport
GO:0033962 P-body assembly
GO:0034063 stress granule assembly
GO:0035578 azurophil granule lumen
GO:0035973 aggrephagy
GO:0043312 neutrophil degranulation
GO:0045505 dynein intermediate chain binding
GO:0051293 establishment of spindle localization
GO:0051301 cell division
GO:0051959 dynein light intermediate chain binding
GO:0060236 regulation of mitotic spindle organization
GO:0070062 extracellular exosome
GO:0072382 minus-end-directed vesicle transport along microtubule
GO:0090235 regulation of metaphase plate congression
GO:0097711 ciliary basal body-plasma membrane docking
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904115 axon cytoplasm
GO:1905832 positive regulation of spindle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR004273 Dynein heavy chain region D6 P-loop domainDomainDomain
IPR013594 Dynein heavy chain, tailDomainDomain
IPR013602 Dynein heavy chain, linkerDomainDomain
IPR024317 Dynein heavy chain, AAA module D4DomainDomain
IPR024743 Dynein heavy chain, coiled coil stalkDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor regionDomainDomain
IPR035706 Dynein heavy chain, ATP-binding dynein motor regionDomainDomain
IPR041228 Dynein heavy chain, C-terminal domainDomainDomain
IPR041466 Dynein heavy chain, AAA 5 extension domainDomainDomain
IPR041658 Dynein heavy chain AAA lid domainDomainDomain
IPR042219 Dynein heavy chain AAA lid domain superfamilyFamilyHomologous superfamily
IPR042222 Dynein heavy chain, domain 2, N-terminalFamilyHomologous superfamily
IPR042228 Dynein heavy chain, linker, subdomain 3FamilyHomologous superfamily
IPR043157 Dynein heavy chain, AAA1 domain, small subdomainFamilyHomologous superfamily
IPR043160 Dynein heavy chain, C-terminal domain, barrel regionFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DYHC1_HUMANBICL1_MOUSEBioGRID20360680 details
DYHC1_HUMANBICL2_MOUSEBioGRID20360680 details