Entity Details

Primary name BECN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14457
EntryNameBECN1_HUMAN
FullNameBeclin-1
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesBECN1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0019898 extrinsic component of membrane
GO:0030425 dendrite
GO:0032465 regulation of cytokinesis
GO:0033197 response to vitamin E
GO:1902902 negative regulation of autophagosome assembly
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:0000422 autophagy of mitochondrion
GO:0000423 mitophagy
GO:0005789 endoplasmic reticulum membrane
GO:0007080 mitotic metaphase plate congression
GO:0010008 endosome membrane
GO:0034198 cellular response to amino acid starvation
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II
GO:0043066 negative regulation of apoptotic process
GO:0043652 engulfment of apoptotic cell
GO:0050790 regulation of catalytic activity
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:2000786 positive regulation of autophagosome assembly
GO:0000045 autophagosome assembly
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0007040 lysosome organization
GO:0008285 negative regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016236 macroautophagy
GO:0032801 receptor catabolic process
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0048666 neuron development
GO:0051020 GTPase binding
GO:0051301 cell division
GO:0071275 cellular response to aluminum ion
GO:0071280 cellular response to copper ion
GO:1905672 negative regulation of lysosome organization
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
GO:0000407 phagophore assembly site
GO:0005776 autophagosome
GO:0006968 cellular defense response
GO:0006995 cellular response to nitrogen starvation
GO:0007568 aging
GO:0010040 response to iron(II) ion
GO:0010288 response to lead ion
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031966 mitochondrial membrane
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I
GO:0035032 phosphatidylinositol 3-kinase complex, class III
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045022 early endosome to late endosome transport
GO:0045324 late endosome to vacuole transport
GO:0045335 phagocytic vesicle
GO:0050435 amyloid-beta metabolic process
GO:0051607 defense response to virus
GO:0060548 negative regulation of cell death
GO:0070301 cellular response to hydrogen peroxide
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098780 response to mitochondrial depolarisation

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Endosome membrane
Golgi apparatus
Endosome
Mitochondrion
Cytoplasmic vesicle
Mitochondrion membrane
Nucleus

Domains

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DomainNameCategoryType
IPR007243 Atg6/BeclinFamilyFamily
IPR029318 Beclin-1, BH3 domainDomainDomain
IPR032913 Beclin-1FamilyFamily
IPR038274 Atg6/Beclin C-terminal domain superfamilyFamilyHomologous superfamily
IPR040455 Atg6, BARA domainDomainDomain
IPR041691 Atg6/beclin, coiled-coil domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00783 EstradiolDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule

Interactions

3 interactions