Entity Details

Primary name ITPR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14643
EntryNameITPR1_HUMAN
FullNameInositol 1,4,5-trisphosphate receptor type 1
TaxID9606
Evidenceevidence at protein level
Length2758
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesITPR1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005509 calcium ion binding
GO:0005637 nuclear inner membrane
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0009791 post-embryonic development
GO:0010506 regulation of autophagy
GO:0014069 postsynaptic density
GO:0015085 calcium ion transmembrane transporter activity
GO:0015278 calcium-release channel activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0019855 calcium channel inhibitor activity
GO:0030168 platelet activation
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031088 platelet dense granule membrane
GO:0031094 platelet dense tubular network
GO:0031095 platelet dense tubular network membrane
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0035091 phosphatidylinositol binding
GO:0042045 epithelial fluid transport
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0050849 negative regulation of calcium-mediated signaling
GO:0050882 voluntary musculoskeletal movement
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098695 inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000493 Inositol 1,4,5-trisphosphate receptorFamilyFamily
IPR000699 RIH domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016093 MIR motifDomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB03401 1D-myo-inositol 1,4,5-trisphosphateDrugbanksmall molecule
DB09462 GlycerinDrugbanksmall molecule
DB11590 ThimerosalDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink