Entity Details

Primary name IRF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14653
EntryNameIRF3_HUMAN
FullNameInterferon regulatory factor 3
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF3

GO terms

Show/Hide Table
GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016032 viral process
GO:0019904 protein domain specific binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050727 regulation of inflammatory response
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071888 macrophage apoptotic process
GO:0097300 programmed necrotic cell death
GO:0098586 cellular response to virus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

3 interactions