Entity Details

Primary name FGFR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP16092
EntryNameFGFR1_MOUSE
FullNameFibroblast growth factor receptor 1
TaxID10090
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesFgfr1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001759 organ induction
GO:0001837 epithelial to mesenchymal transition
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0007605 sensory perception of sound
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010763 positive regulation of fibroblast migration
GO:0010863 positive regulation of phospholipase C activity
GO:0010966 regulation of phosphate transport
GO:0010976 positive regulation of neuron projection development
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019827 stem cell population maintenance
GO:0021769 orbitofrontal cortex development
GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration
GO:0021847 ventricular zone neuroblast division
GO:0021954 central nervous system neuron development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0031175 neuron projection development
GO:0031410 cytoplasmic vesicle
GO:0033674 positive regulation of kinase activity
GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043583 ear development
GO:0044877 protein-containing complex binding
GO:0045597 positive regulation of cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0048339 paraxial mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0048514 blood vessel morphogenesis
GO:0048699 generation of neurons
GO:0048762 mesenchymal cell differentiation
GO:0050729 positive regulation of inflammatory response
GO:0050839 cell adhesion molecule binding
GO:0051174 regulation of phosphorus metabolic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0051930 regulation of sensory perception of pain
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060117 auditory receptor cell development
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0070640 vitamin D3 metabolic process
GO:0072091 regulation of stem cell proliferation
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090272 negative regulation of fibroblast growth factor production
GO:0090722 receptor-receptor interaction
GO:1903465 positive regulation of mitotic cell cycle DNA replication
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000830 positive regulation of parathyroid hormone secretion
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR028174 Fibroblast growth factor receptor 1, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

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