Entity Details

Primary name CASP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14790
EntryNameCASP8_HUMAN
FullNameCaspase-8
TaxID9606
Evidenceevidence at protein level
Length479
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCASP8

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001817 regulation of cytokine production
GO:0004197 cysteine-type endopeptidase activity
GO:0005123 death receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007507 heart development
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009409 response to cold
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0019054 modulation by virus of host cellular process
GO:0030101 natural killer cell activation
GO:0030225 macrophage differentiation
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035877 death effector domain binding
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0039650 suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0046677 response to antibiotic
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0070269 pyroptosis
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071550 death-inducing signaling complex assembly
GO:0097110 scaffold protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097264 self proteolysis
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097342 ripoptosome
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001875 Death effector domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site
IPR033170 Caspase-8FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB11752 Bryostatin 1Drugbanksmall molecule
DB12651 BardoxoloneDrugbanksmall molecule