Entity Details

Primary name SETB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15047
EntryNameSETB1_HUMAN
FullNameHistone-lysine N-methyltransferase SETDB1
TaxID9606
Evidenceevidence at protein level
Length1291
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesSETDB1

GO terms

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GOName
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0007265 Ras protein signal transduction
GO:0008270 zinc ion binding
GO:0010629 negative regulation of gene expression
GO:0018024 histone-lysine N-methyltransferase activity
GO:0033273 response to vitamin
GO:0043231 intracellular membrane-bounded organelle
GO:0045471 response to ethanol
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0051567 histone H3-K9 methylation
GO:0070828 heterochromatin organization
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001739 Methyl-CpG DNA bindingDomainDomain
IPR002999 Tudor domainDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR007728 Pre-SET domainDomainDomain
IPR016177 DNA-binding domain superfamilyFamilyHomologous superfamily
IPR025796 Histone-lysine N-methyltransferase SETDB1FamilyFamily
IPR040880 Domain of unknown function DUF5604DomainDomain
IPR041291 Histone methyltransferase, Tudor domain 1DomainDomain
IPR041292 Histone methyltransferase, Tudor domain 2DomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SETB1_HUMANHACD3_MOUSEIntAct25036637 details