Entity Details

Primary name RHEB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15382
EntryNameRHEB_HUMAN
FullNameGTP-binding protein Rheb
TaxID9606
Evidenceevidence at protein level
Length184
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesRHEB

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005681 spliceosomal complex
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0070062 extracellular exosome
GO:0120163 negative regulation of cold-induced thermogenesis
GO:2000074 regulation of type B pancreatic cell development

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR037586 GTP-binding protein RhebFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
RHEB_HUMANDP13A_MOUSEBioGRID, IntAct20368287 details
RHEB_HUMANGO45_MOUSEBioGRID, IntAct20368287 details
RHEB_HUMANTRAF2_MOUSEBioGRID, IntAct20368287 details