Entity Details

Primary name TERF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15554
EntryNameTERF2_HUMAN
FullNameTelomeric repeat-binding factor 2
TaxID9606
Evidenceevidence at protein level
Length542
SequenceStatuscomplete
DateCreated2002-06-20
DateModified2021-06-02

Ontological Relatives

GenesTERF2

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0001673 male germ cell nucleus
GO:0001701 in utero embryonic development
GO:0003691 double-stranded telomeric DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0007004 telomere maintenance via telomerase
GO:0008022 protein C-terminus binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016233 telomere capping
GO:0016604 nuclear body
GO:0019899 enzyme binding
GO:0031627 telomeric loop formation
GO:0031848 protection from non-homologous end joining at telomere
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032204 regulation of telomere maintenance
GO:0032205 negative regulation of telomere maintenance
GO:0032206 positive regulation of telomere maintenance
GO:0032208 negative regulation of telomere maintenance via recombination
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032214 negative regulation of telomere maintenance via semi-conservative replication
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
GO:0044877 protein-containing complex binding
GO:0045007 depurination
GO:0048239 negative regulation of DNA recombination at telomere
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0061820 telomeric D-loop disassembly
GO:0070187 shelterin complex
GO:0070198 protein localization to chromosome, telomeric region
GO:0090398 cellular senescence
GO:0098505 G-rich strand telomeric DNA binding
GO:0099087 anterograde axonal transport of messenger ribonucleoprotein complex
GO:1900051 positive regulation of histone exchange
GO:1903770 negative regulation of beta-galactosidase activity
GO:1903824 negative regulation of telomere single strand break repair
GO:1904115 axon cytoplasm
GO:1904354 negative regulation of telomere capping
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:1904430 negative regulation of t-circle formation
GO:1905778 negative regulation of exonuclease activity
GO:1905839 negative regulation of telomeric D-loop disassembly
GO:2000773 negative regulation of cellular senescence

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR013867 Telomere repeat-binding factor, dimerisation domainDomainDomain
IPR017357 Telomeric repeat-binding factor 1/2FamilyFamily
IPR017930 Myb domainDomainDomain
IPR030657 Telomeric repeat-binding factor 2FamilyFamily
IPR031902 Telomeric repeat-binding factor 2, Rap1-binding domainDomainDomain
IPR036507 Telomere repeat-binding factor, dimerisation domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TERF2_HUMANPP1RA_MOUSEBioGRID, DIP, IntAct19287395 20360068 details