Entity Details

Primary name NCOA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15596
EntryNameNCOA2_HUMAN
FullNameNuclear receptor coactivator 2
TaxID9606
Evidenceevidence at protein level
Length1464
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesNCOA2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0010906 regulation of glucose metabolic process
GO:0015721 bile acid and bile salt transport
GO:0016604 nuclear body
GO:0016922 nuclear receptor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0019904 protein domain specific binding
GO:0030374 nuclear receptor coactivator activity
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0045475 locomotor rhythm
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0060765 regulation of androgen receptor signaling pathway
GO:1904017 cellular response to Thyroglobulin triiodothyronine

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010011 Nuclear receptor coactivator, DUF1518DomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlockingDomainDomain
IPR014935 Nuclear receptor coactivator, receptor-binding domainDomainDomain
IPR017426 Nuclear receptor coactivatorFamilyFamily
IPR028822 Nuclear receptor coactivator 2FamilyFamily
IPR032565 Domain of unknown function DUF4927DomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB02998 MetriboloneDrugbanksmall molecule
DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENINDrugbanksmall molecule
DB06898 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07086 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07087 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07195 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07678 (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07707 (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07863 2-chloro-5-nitro-N-phenylbenzamideDrugbanksmall molecule
DB07932 dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateDrugbanksmall molecule
DB08047 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolDrugbanksmall molecule
DB08048 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDrugbanksmall molecule
DB08320 DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATEDrugbanksmall molecule
DB08398 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridineDrugbanksmall molecule
DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDrugbanksmall molecule
DB08595 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB08601 TributyltinDrugbanksmall molecule
DB08773 2-(4-hydroxyphenyl)benzo[b]thiophen-6-olDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule

Interactions

4 interactions