Entity Details

Primary name TRADD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15628
EntryNameTRADD_HUMAN
FullNameTumor necrosis factor receptor type 1-associated DEATH domain protein
TaxID9606
Evidenceevidence at protein level
Length312
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTRADD

GO terms

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GOName
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0019900 kinase binding
GO:0030335 positive regulation of cell migration
GO:0031264 death-inducing signaling complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051798 positive regulation of hair follicle development
GO:0070513 death domain binding
GO:0071356 cellular response to tumor necrosis factor
GO:0071550 death-inducing signaling complex assembly
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR009095 TRADD, N-terminalDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR035712 TRADDFamilyFamily
IPR036729 TRADD, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
TRADD_HUMANFADD_MOUSEMINT8565075 details
TRADD_HUMANTNR1A_MOUSEBioGRID, HPIDb, IntAct11374864 7758105 details
TRADD_HUMANPPARG_MOUSEBioGRID27197753 details